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Research Papers Haemophilia

Haemophilia Journal - World Federation of Hemophilia Haemophilia Journal - World Federation of Hemophilia
Haemophilia. Haemophilia, published by Wiley-Blackwell, is the official journal of the World Federation of Hemophilia. Dedicated to the exchange of information ...

Research Papers Haemophilia

He was appointed principal investigator at the cambridge institute for medical research in 1999, university reader in 2007 and professor of molecular haemostasis in 2011. We recently opened our state-of-the-art laboratory at the stevenage biosciences catalyst, a short 20-minute train north of london. He has written over 135 articles published in national and international peer-reviewed journals, including professor massberg is the co-ordinator and lead scientist of the european fp7 project prestige, the co-speaker and principal investigator of the dfg collaborative research unit (sfb) 914 and the principal investigator of the dfg-research unit (for) 923.

Design and deliver it solutions to meet the needs of a rapidly growing organization gather and evaluate business needs by gathering information, evaluating needs, anticipating requirements and uncovering areas for improvement including designing a full it system roadmap evaluate system and software solutions and communicate practical system recommendations including cost estimates document and design new processes workflows and communicate clearly difficult concepts to non-technical internal users translating business requirements into functional requirements and writing specifications documents working with itfinance & procurement in the organisation to provide technical input to conduct formal rfp procurement processes and provide technical evaluation of responses to successfully procure systems and software work independently and collaborate with functional colleagues to deliver it projects on time and within budget trouble shoot and provide ad hoc support to investigate ongoing or one-time operational issues and determine solutions and creative work arounds provide staff training on our key systems and inductions for new starters on key software a bachelors degree preferably in it or computer science or alternatively relevant it experience minimum of 5 years experience working in it related project management with operational experience or experience in a very closely related field excellent spoken and written communication skills with great attention to detail for developing documentation strong time management skills, self-motivated, solution orientated and able to organise own workload good interpersonal skills and relationship builder with the ability to influence internal and external stakeholders creative and inquisitive with good analytical, critical thinking and problem-solving skills be part of the gmp manufacturing operations team responsible for delivering gmp manufacturing batches for clinical studies. He has been post-doctoral fellow at mcmaster university, hamilton, ontario and guest or visiting scientist at mcmaster university, hamilton, ontario, temple university, philadelphia and the scripps research institute, la jolla, california. He is co-author of more than 180 indexed articles, mostly on hit and published in blood, circulation, journal of thrombosis and haemostasis and thrombosis and haemostasis.

The successful candidate will lead challenging and rewarding research projects in an environment that relies on tenacity, perseverance and collaboration. His main research interests focus on pathophysiology of primary haemostasis, pharmacology of antiplatelet agents and the role of homocysteine in thrombotic disease. Most recently, they observed that net formation is enhanced by cancer, diabetes, and the aging process conditions that promote inflammation and thrombosis.

He obtained a phd from vanderbilt university in 1997 for work on the biophysical characterisation of members of the serpin family of proteins with peter gettins. He is also president of the french study group on hemostasis and thrombosis (groupe français detudes sur lhémostase et la thrombose gfht) since 2013. The internalised qc laboratory supports the freeline gmp manufacturing capability  and regulated  bioanalytical testing for freeline preclinical and clinical programmes.

Head dd biologhy, at idorsia pharmaceuticals ltd. Freeline material receiving warehouse and manufacturing teams. This is a strategic yet hands on role requiring someone who can work independently and who can balance priorities and deliver pragmatic solutions quickly.

From 1999 to 2007 she worked as postdoctoral fellow and as researcher at the research institute of the hospital vall dhebron in barcelona (spain), participating in projects investigating the mechanisms and consequences of platelet activation during acute myocardial infarction. Qc annexes ich quality topics eu and us bioanalytical method validation) detailed understanding of requirements of analytical methods validation and an awareness of all relevant pertaining guidance and regulations demonstrable knowledge of the documentation requirements for gxp quality control and bioanalysis including maintenance of data integrity, computer systems validation, equipment procurement and qualification working within controlled document systems, the faithful reporting of data, generation of certificates, protocols, sops and written reports experience of working in pharmaceutical field within a qms and of working in collaboration with quality assurance professionals, including auditing programs experience of working across multi-disciplinary, multi-cultural teams and with external partners a wide range of analytical techniques and expertise in analytical development evidenced by publications experience of analytical process science, andor formulation science for viral gene therapy products professional qualifications with independent recognition by learned societies as part of building capability to drive our portfolio forwards,  you will join a rapidly growing world-class multidisciplinary team and to engage in laboratory science at this exciting new biotechnology venture. He is recipient of the spinoza award, which is the highest scientific prize in the netherlands, is elected fellow of the royal academy of arts and sciences in the netherlands, and of the german academy leopoldina, and received an honorary doctorate from the university of paris descartes. As a board-certified academic cardiothoracic surgeon, he has over 15 years of past clinical experience while also serving as a primary investigator in basic science and clinical research. His contributions include research into the medicinal chemistry and mechanisms of action of oligonucleotide-based drugs in cell culture and in animals, and in the establishment of numerous preclinical and clinical programs, many of which have resulted in clinical proof of concept across a broad range of therapeutic areas, including oncology, cardio-metabolic diseases, inflammation, respiratory diseases, neurodegenerative diseases, and rare diseases.


Haemophilia - Wikipedia


Haemophilia is a mostly inherited genetic disorder that impairs the body's ability to make blood clots, a process needed to stop bleeding. This results in people ...

Research Papers Haemophilia

Invited Speakers - ECTH 2018
FRITS ROSENDAAL. Frits Rosendaal is professor of Clinical Epidemiology at the Leiden University Medical Center. He has a long standing track record in research in ...
Research Papers Haemophilia Darauf aufbauend wurde ein firmeneigenes aav-kapsid entwickelt, welches einen noch effizienteren gentransfer in die leber und somit die dauerhafte expression eines gewünschten proteins in großen mengen ermöglicht, Write and review sops. He designed several studies, such as lets and mega,  that were instrumental in the identification of a series of risk factors for thrombosis, which ranged from genetic factors to environmental ones, particularly related to drug safety, such as specific brands of oral contraceptives. He received his doctorate in biomedical science from the university of portsmouth in 2003 for a thesis on lupus anticoagulant detection. She is a member of the scientific advisory board of the dutch thrombosis foundation. Ability to identify issues as they occur and report accordingly with all relevant information. Her research interests are haemorrhagic disorders, particularly in treatment of haemophiliacs and haemophiliacs with inhibitors, He was chair of the working party on platelet aggregation, and chair of the scientific subcommittee on platelet physiology, scientific and standardization committee, isth. The successful candidate will lead challenging and rewarding research projects in an environment that relies on tenacity, perseverance and collaboration. In enger zusammenarbeit mit dem bereich lab support berichten sie an den teamleiter assayentwicklung.
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    His basic-science research topics include stem-cell biology, platelet biology, mechanisms of arterial and venous thrombosis, immune-cell migration, immune-cellcoagulation crosstalk and bio-imaging (including 2-photon microscopy). Bianchi bonomi haemophilia and thrombosis centre and institute of internal medicine at the ospedale maggiore, università degli studi di milano. His research activities are mainly focussed on the factor viiivon willebrand factor (fviiivwf) complex and the related disorders haemophilia a and von willebrand disease. Dr carmen escuriola ettingshausen is the director of the haemophilia centre rhein main hzrm, frankfurt-mörfelden, germany. Prior to his current role, he trained in diagnostic haematology at the hospital for sick children at great ormond street, spent seven years at the royal london hospital, and then took charge of the barts coagulation laboratories for three years.

    To work closely with facility and other supporting teams to ensure requirements for manufacture are met. He received his doctorate in biomedical science from the university of portsmouth in 2003 for a thesis on lupus anticoagulant detection. Marco cattaneo is professor of internal medicine and director of the unit of internal medicine at ospedale san paolo, università degli studi di milano, italy. Biology from the massachusetts institute of technology. Our recent series b funding round of 88m has enabled the recruitment of the brightest scientists, who drive their projects using the best available or novel cutting-edge technologies.

    In the field of haemophilia, he oversees the haemophilia in the netherlands national projects, and is involved in studies of inhibitor development, again in the context of drug safety. He obtained a phd from vanderbilt university in 1997 for work on the biophysical characterisation of members of the serpin family of proteins with peter gettins. Weitere indikationen befinden sich bereits in der vorbereitung zur klinik. In 2015, he joined the faculty of pharmacy, aix marseille university, as professor in cell biology. His research activities are mainly focused on the mechanisms involved in thrombus formation and in thrombosis associated with cancer. Set an example to other colleagues, and to train and mentor junior staff in appropriate techniques for experienced candidates, supervision of one or more research associatesscientists and the potential to lead pre-clinical programs a phd-degree in biochemistry or relevant biological discipline or equivalent level of professional qualifications hands-on experience purifying tagged and non-tagged proteins from cell culture is essential purification from complex biological material such as plasma or tissues is strongly preferred experience with akta purification systems and unicorn software is strongly preferred experience in enzymology of proteases (e. Barbara and bruce furies lab at boston, ma. Unsere vision ist es, menschen mit chronischen erkrankungen ein besseres leben zu ermöglichen, indem wir das potenzial der gentherapie zur heilung von patienten mit einer nur einmal benötigten medikation nutzen. Martine jandrot-perrus has devoted her research to understanding the mechanisms leading to the formation of a clot (physiological) thrombus (pathological), with a particular interest for the processes taking place at the interface between the plasma (coagulation), the cells (platelets) and fibrin (fibrinolysis). This is a key laboratory-based, hands-on operational role ensuring delivery of the qc service, critical to corporate strategies.

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    Careers | Freeline

    Careers. We are based in Stevenage at the Stevenage Bioscience Catalyst, London at the Royal Free NHS Foundation Trust and Munich and are looking to expand our team.
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    He has published more than 400 papers on these topics and contributed to many textbooks in thrombosis and hemostasis. Freeline has a clear focus on aav based gene therapy targeting the liver with the aim to provide treatments for diseases with significant unmet needs. Between 20, he held a position of director of protein & antibody discovery at crucell holland (leiden, the netherlands). After graduating, he worked as a chemist at alza corporation in california for three years evaluating compounds that enhanced the electrotransport of drugs across the skin. Experience of working in a highly regulated industry pharmaceuticals or biotechnology erp system experience with working knowledge of purchasing and inventory modules would be advantageous Buy now Research Papers Haemophilia

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    He specialized for transfusion medicine, immuno hematology and clinical immunology at the university giessen, germany. He has published more than 400 papers on these topics and contributed to many textbooks in thrombosis and hemostasis. Hierbei zählen vor allem die kontrolle und weiterentwicklung unseres bisherigen qualitätsmanagement systems im bereich labor, dokumentation, arbeitsanweisungen, wareneingang- und beschaffung sowie geräteinstandhaltung zu ihren hauptaufgaben. In 2012 she founded the haemophilia centre rhein-main, frankfurt-mörfelden. He is a fellow of the institute of biomedical sciences (uk) and a fellow of the academy of clinical science and laboratory medicine (ireland )and an assistant adjunct professor in health service management in trinity college, dublin Research Papers Haemophilia Buy now

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    Funktionalität dieses optimierten aav kapsids wird aktuell an weiteren hämophilie b patienten in einer zweiten klinischen studie validiert, deren bisherige ergebnisse die eignung dieses therapieansatzes für eine angestrebte heilung der patienten nach einmaliger behandlung bestätigen. Guy meyer is professor of respiratory medicine at paris descartes university and chief of the department of respiratory and intensive care medicine at hôpital europeen georges pompidou in paris. A phd-degree in a relevant biological discipline or equivalent level of professional qualifications scientific training and background in one or more of the following areas cell and gene therapy, preparation of peptide displayvariant libraries, novel barcoding and next generation sequencing techniques, bioinformatics, high through-put screening assays for aav variants Buy Research Papers Haemophilia at a discount

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    Demonstrates working knowledge of biologics and or atmps and imp manufacturing significant experience and or familiarisation with microsoft office applications (specifically outlook, word, excel and powerpoint) freeline therapeutics ltd. Regelmäßige interaktion mit kollegen bereitet ihnen freude. Execution of analytical testing programmes as directed by the qc manager, according to gxp, with defined schedules and responsibilities following sops and protocols, effective performance of analytical methods generating valid and reliable data accurate and compliant data recording and reporting of all data, per sops, including peer review checking effective team working within qc and across company departments where required routine maintenance, verification and qualification of specified analytical systems interaction with quality professionals and responding to audit findings as required by the qc manager participation in analytical investigations when required, within a culture of continuous improvement, and notification of unusual observations, errorsunexpected findings to management compliance with health and safety legislation and company policies,  identification of potential hazards in the workplace degree with experience in the analytical sciences gained during development of biotechnologybiopharmaceuticalsvaccines either in industry andor research significant experience in physicochemical, biochemical, and biological assays in a variety of applications, including two or more of knowledge of analytical methods validation and an awareness of guidance and regulations contribution to reporting of data, generation of certificates, protocols, sops and internal written reports good communication skills and the ability to present and explain data (internally and externally) a flexible approach plus the ability to work to set priorities and deliver projects on time in a fast moving agile work environment self-motivated individual with the ability to work with multi-disciplinary, multi-cultural teams achieving a high standard of work experience of gxp documentation requirements for quality control and bioanalysis, with an emphasis on data integrity and ensuring confidentiality at all times stevenage, ukfreeline is a privately-held clinical-stage biotechnology company based in the uk and germany Buy Online Research Papers Haemophilia

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    Brian omahony is the chief executive of the irish haemophilia society,  president of the european haemophilia consortium and former president of the world federation of hemophilia. Our proprietary aav capsid is optimised to effectively transduce human liver cells and thus provide sustainable, high levels of the desired protein. Monia has also served as president of the oligonucleotide therapeutics society (ots), and currently serves on the board of directors for dynacure therapeutics and as an adjunct professor of biology at san diego state university. She is associate editor for research and practice in thrombosis and haemostasis and member of the editorial board for the journal of thrombosis and haemostasis and plos medicine Buy Research Papers Haemophilia Online at a discount

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    Christophe dubois grew up in perpignan, south of france. Daily administrative duties, including checking delivery documents, booking materials in. He has received many prizes for his work, the most recent being the 2011 martin villar haemostasis award (together with dr bernd engelmann) and the 2012 basic science award from the german society of cardiology (dgk). Thomas hospitals in 1997 as a chief and later a principal biomedical scientist, becoming a consultant scientist in 2008. Sie haben ein abgeschlossenes studium (bachelor, master oder diplom) der biologie, biotechnologie oder biochemie oder eine vergleichbare ausbildung mit biologischem hintergrund und somit ein grundverständnis für biologische zusammenhänge Research Papers Haemophilia For Sale

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    Design and deliver it solutions to meet the needs of a rapidly growing organization gather and evaluate business needs by gathering information, evaluating needs, anticipating requirements and uncovering areas for improvement including designing a full it system roadmap evaluate system and software solutions and communicate practical system recommendations including cost estimates document and design new processes workflows and communicate clearly difficult concepts to non-technical internal users translating business requirements into functional requirements and writing specifications documents working with itfinance & procurement in the organisation to provide technical input to conduct formal rfp procurement processes and provide technical evaluation of responses to successfully procure systems and software work independently and collaborate with functional colleagues to deliver it projects on time and within budget trouble shoot and provide ad hoc support to investigate ongoing or one-time operational issues and determine solutions and creative work arounds provide staff training on our key systems and inductions for new starters on key software a bachelors degree preferably in it or computer science or alternatively relevant it experience minimum of 5 years experience working in it related project management with operational experience or experience in a very closely related field excellent spoken and written communication skills with great attention to detail for developing documentation strong time management skills, self-motivated, solution orientated and able to organise own workload good interpersonal skills and relationship builder with the ability to influence internal and external stakeholders creative and inquisitive with good analytical, critical thinking and problem-solving skills be part of the gmp manufacturing operations team responsible for delivering gmp manufacturing batches for clinical studies For Sale Research Papers Haemophilia

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    He is the head of the department of hemostasis in trousseau hospital (tours) with a bio-clinical activity focusing on congenital and acquired bleeding and thrombotic disorders. Before joining the pharmaceutical industry, michael served as senior research investigator for the heart failure research group at university of pennsylvania. Since 1994 he is head of the department of transfusion medicine at the universitätsmedizin greifswald were he helds a full professorship in transfusion medicine. Professor johannes oldenburg, md, is currently director of the institute of experimental haematology and transfusion medicine and of the haemophilia center, university clinic bonn. Then he moved to the united states in the dr Sale Research Papers Haemophilia

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